Salvia officinalis is the scientific name for common sage. Native to the Middle East and Mediterranean areas, this ingredient is renowned for many constituents, such as alkaloids, carbohydrates, fatty acids, glycosidic derivatives, phenolic compounds, steroids, terpenes, acetylenes, and waxes. In the context of dental and oral health, this ingredient’s anticancer and antimutagenic effects might help end “oral cavity squamous cell carcinoma.” As we dug further into these claims, our editorial team found another source confirming Sage’s ability to protect against microbes (Streptococcus mutans and Candida albicans) that promote dental plaque and cavities.

Eugenia aromatica is an evergreen tree whose flower buds are known as cloves. Cloves, as we are all likely familiar with, have been used in hot beverages and cooking, but sometimes, people need to be reminded of their therapeutic effects. Regarding nutrients, cloves contain fiber, vitamins, and minerals, including manganese. One source noted manganese’s positive influence on building strong bones and brain function. Likewise, its antioxidant activity is poised to reduce oxidative stress, which, as we mentioned earlier, contributes to the deactivation of MSCs.

Regarding cloves’ possible effects on oral health, the same source highlighted their antimicrobial properties, which might halt the growth of bacteria, thereby improving oral hygiene. When its underlying mechanism was further investigated, our editorial team also learned about clove’s role in reducing gum swelling and irritation (attributed to its anti-inflammatory properties), increasing circulation, remineralizing teeth (attributed to the protective properties of eugenol), and possibly decreasing decalcification.

Ferulic acid is a plant-based antioxidant belonging to a group of acids called hydroxycinnamic acids that are usually used in skin care products to reduce inflammation and visible aging signs. In skin health, this ingredient has been shown to repair and protect damaged skin cells, protect the skin from harmful UV rays, and brighten the skin. How about oral health? Two sources covered the combined effects of phloretin and ferulic acid, underscoring the duo’s significant impact on “cell proliferation and healing in oral cells.” Moreover, it can improve gum tissue’s appearance and ease gingival’s damaging effects, among others.

Aloe is a cactus-like plant cultivated for its gel-like substance within the leaves. It has been extensively studied for its hydrating properties; however, when it comes to oral health, it might be helpful as an alternative to mouthwash. One older study suggested that aloe vera’s healthy dose of vitamin C might help block out plaque and reduce the risk of bleeding and swollen gums. Building on its oral health benefits, another source noted that aloe vera might prevent caries and accumulation of oral biofilm, directly halting bacteria. Moreover, its antioxidant property is thought to remineralize teeth and prevent the loss of tooth enamel (especially in the elderly).

Thymus vulgaris extract, made from the thyme herb, belongs to the mint family. It is one of several herbs known for its therapeutic effects in various health areas. Given that this ingredient belongs to the mint family, it should be too much of a surprise that it might be found in toothpaste and mouthwash formulas. A recent 2024 study examining the effects of thyme mouthwash on oral hygiene showed significant improvement in reversing bad breath and gingivitis in patients. These results stem from measuring the herb’s impact on intraoral halitosis, gingival index, and plaque index.

Regarding the mint family, peppermint is another ingredient in the ProXental™ formula. It carries antibacterial, antifungal, antiviral, larvicidal, antitumor, radioprotective, chemoprotective, genotoxicity, hepatoprotective, antioxidant, anti-inflammatory, antidiabetic, and neuroprotective effects. Some of the properties combined have helped the plant gain recognition for its powerful effects on fighting off oral pathogens and bacteria linked to cavities and gum disease.

Xylitol is described as a naturally occurring sugar alcohol that is often used as a sweetener. Interestingly, it is found in many oral health products such as toothpaste, mouthwash, floss, chewing gums, and mints. The reason for this dates back to the first findings in 1975, where xylitol reduces dental caries and gum disease incidence and improves oral health. Additionally, xylitol has been proven to slow the destruction of enamel (while increasing the production of new enamel), prevent the formation of new cavities, and prevent S.mutans from expanding.

The last ingredient is cucumber. From the looks of things, this ingredient’s antioxidant and anti-inflammatory properties have been helpful in terms of possibly treating malignant oral disorders like oral leukoplakia, oral submucous fibrosis, and oral lichen planus. In other words, its role in neutralizing free radicals and oxidative stress and reversing the consequences of the duo on oral health has earned it a spot in the oral health space. To add to its list of benefits, cucumbers are also believed to alkalinize saliva, which might help remineralize enamel and fight bacteria linked to cavity formation.